Famotidine decreases the amount of acid the stomach produces and is used to treat certain gastrointestinal conditions characterized by high acid production. Famotidine reduces the secretion of gastric acid in the stomach by blocking the effect of histamine on histamine H2-receptors located on the parietal cells lining the stomach wall. Histamine is the chemical transmitter that stimulates the parietal cells to release gastric acid. By blocking H2 receptors, famotidine prevents. Famotidine, sold under the brand name Pepcid among others, is an histamine H 2 receptor antagonist medication that decreases stomach acid production. It is used to treat peptic ulcer disease, gastroesophageal reflux disease, and Zollinger-Ellison syndrome. It is taken by mouth or by injection into a vein. It begins working within an hour. Common side effects include headache, intestinal upset. La famotidine est un antagoniste compétitif des récepteurs H2 de l'histamine, qui provoque l'inhibition de la sécrétion d'acide gastrique contrôlée par les récepteurs H2. En plus des taux d'acidité gastrique, elle diminue le taux de pepsine, et, dans une moindre mesure, le volume de la sécrétion gastrique basale et sous stimulation. Il n'a été observé aucun effet pharmacologique sur le SNC, sur les systèmes immunitaire, cardiovasculaire ou respiratoire. H 2 -receptor antagonism is reported to result in a 70% to 90% reduction in acid production. 13 Famotidine is more effective at suppressing gastric acid secretion relative to ranitidine. Famotidine is well tolerated, although, with chronic therapy, there is the potential for hypoacidity and gastric bacterial overgrowth. La famotidine a pour effet de diminuer la production d’acide gastrique. Famotidine is used to relieve symptoms of acid reflux and heartburn. It does this by reducing the amount of acid in your stomach. It treats the following conditions: Famotidine is used to treat and prevent ulcers in the stomach and intestines. It also treats conditions in which the stomach produces too much acid, such as Zollinger-Ellison syndrome. Famotidine also treats gastroesophageal reflux disease and other conditions in which acid backs up from the stomach into the esophagus, causing heartburn. Famotidine is a histamine type 2 receptor antagonist (H2 blocker) which is commonly used for treatment of acid-peptic disease and heartburn. Famotidine has been linked to rare instances of clinically apparent acute liver injury. Famotidine is a member of 1,3-thiazoles, a sulfonamide and a member of guanidines. Elle réduit la quantité d'acide sécrété par l'estomac. La famotidine vendue sans ordonnance s'utilise dans le traitement des affections nécessitant une réduction de l'acide gastrique, comme l'indigestion, les brûlures d'estomac ou les aigreurs ou irritations d'estomac. - La famotidine réduit la production d'acide et de pepsine, ainsi que le volume de la sécrétion gastrique, basale et stimulée. - Après administration orale, le début de l'effet antisécrétoire survient en moins d'une heure, avec un maximum dose-dépendant survenant en 1 à 3 heures.